RAF Typhoon fighter aircraft have joined forces with France's air force in a combined operation against an subterranean weapons facility in Syria employed by the IS group, according to the UK Ministry of Defence.
The location, identified by intelligence, was believed to be storing arms and explosives, the announcement noted, and was positioned in mountains just north of Palmyra in the heart of Syria.
"The RAF jets employed precision-guided Paveway IV munitions to strike a several access tunnels providing entry to the depot... early reports suggest the target was engaged successfully," officials stated.
There was no evidence of any harm to civilians in the attack late on Saturday and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
Daesh - alternatively referred to as Daesh - enforced militant control over parts of Syria and Iraq before its territorial defeat in 2019.
"This strike shows British leadership, and determination to stand shoulder to shoulder with allied nations, to stamp out any revival of IS and their violent and radical beliefs in the region," the British Defence Secretary John Healey said.
RAF aircraft have performed surveillance missions over Syrian airspace to "forestall any attempted comeback" of the group after its defeat at the battle of Baghuz in the year 2019, the authorities noted.
"I want to thank the personnel of the UK armed forces who took part in this mission for their expertise and their valour," he said. "Including them were a great many British personnel stationed over Christmas and New Year. This operation, to remove militants who pose a risk to our way of life, demonstrates how UK forces are ready to step up, continuously, ensuring Britain's security domestically and strong abroad."
Last December, the American forces executed what it called a "major assault" on Islamic State objectives in Syria, following an assault claimed the lives of two US troops and a civilian interpreter in Palmyra.
The UN estimates Islamic State still has between 5,000 and 7,000 militants in both countries.